noun

Severe mental or physical pain or suffering.

she shut her eyes in anguish

agony,pain,torment,torture,suffering,distress,angst,misery,sorrow,grief,heartache,heartbreak,wretchedness,unhappiness,woe,desolation,despair

intransitive verb

Be extremely distressed about something.

he anguished over how to reply

agonized,tormented,racked with pain,racked with suffering,tortured,harrowed