verb

make (someone) insane.

that business last month must have deranged him a bit

insane,mad,of unsound mind,out of one’s mind,not in one’s right mind,disturbed,unbalanced,unhinged,unstable,crazed,demented,irrational,berserk,frenzied,maniac,lunatic,psychopathic,certifiable,raving,raving mad,non compos mentis,sectionable,touched,crazy,cracked,mental,barmy,barking,barking mad,round the twist