noun

a feeling of intense irritation or annoyance.

she rolled her eyes in exasperation

irritation,annoyance,chagrin,vexation,anger,fury,rage,wrath,spleen,ill humour,crossness,tetchiness,testiness,pique,indignation,resentment,disgruntlement,disgust,discontent,displeasure,aggravation,crabbiness,stroppiness,ire,choler,bile