substance

That which has mass and occupies space; matter.

A material of a particular kind or constitution.

A drug, chemical, or other material (such as glue) that one is dependent on or uses habitually and that is often illegal or subject to government regulation.

The most important part or idea of what is said or written; the essence or gist.

That which is real or practical in quality or character; practical value.

Significance or importance.

Density; body.

Material possessions; goods; wealth.