noun

the complete loss or absence of hope.

a voice full of self-hatred and despair

hopelessness,desperation,distress,anguish,pain,unhappiness,dejection,depression,despondency,disconsolateness,gloom,melancholy,melancholia,misery,wretchedness,disheartenment,discouragement,resignedness,forlornness,defeatism,pessimism

verb

lose or be without hope.

we should not despair

lose hope,give up hope,abandon hope,give up,lose heart,be discouraged,be despondent,be demoralized,resign oneself,throw in the towel/sponge,quit,surrender,be pessimistic,look on the black side,despond,hopeless,desperate,anguished,distressed,broken-hearted,heartbroken,grief-stricken,inconsolable,sorrowing,suicidal,in despair,dejected,depressed,despondent,disconsolate,gloomy,melancholy,miserable,wretched,desolate,forlorn,disheartened,discouraged,demoralized,devastated,downcast,resigned,defeatist,pessimistic,dolorous